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Arthritis
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Chemokines and bone remodeling.
Chemokines and bone remodeling.
Int J Immunopathol Pharmacol. 2008 Jul-Sep; 21(3): 485-91
Galliera E, Locati M, Mantovani A, Corsi MM Bone remodeling is characterized by spatial and temporal coupling of bone resorption and formation and is necessary for skeletal growth and normal bone structure maintenance. Imbalance of this process is related to metabolic bone disorders such as osteoporosis or rheumatoid arthritis. For this reason, bone remodeling is under the control of several local and systemic factors, including molecules of the immune system. The importance of the interplay of both the skeletal and immune systems is reflected by the emerging interdisciplinary research field, called osteoimmunology, focused on common aspects of osteology and immunology. This review focuses on the role of inflammatory mediators, such as cytokines in bone remodeling and, in particular, a subfamily of chemotactic cytokines or chemokines which are involved not only in several aspects of physiological bone remodeling but also in pathological bone disorders, such as rheumatoid arthritis or osteoporosis. Understanding the role of inflammation and chemokines will provide new insights for the treatment of diseases affecting both skeletal and immune systems, by the development of new therapeutic strategies targeting common inflammatory mediators.
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Arthritis Treatment
The type of arthritis and intensity of the condition determine the course of treatment. There is no cure for arthritis, but there are traditional and alternative treatments that can bring arthritis pain relief. Prescription and over-the-counter medications are popular for treating arthritis pain. Acetaminophen (Tylenol) is often recommended for osteoarthritis patients with little or mild inflammation, while aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen work best for patients with inflammatory rheumatoid arthritis.
The healing touch of massage may stimulate the flow of blood, bringing heat and relief to stiff joints. Alternative therapies such as acupuncture, relaxation, yoga, and even emu oil are have proven effective for many arthritis sufferers.
Heat and cold can help alleviate pain too, but since moist heat, such as that from a bath, acts differently than the dry heat of a heating pad or the cold of an ice pack, this type of treatment needs to be discussed with a doctor or physical therapist. Doctors also often recommend patients wear splints or braces to relieve joint pressure and protect them from further injury. |
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